Dr. Zsolt Torok

 

Zsolt TÖRÖK PhD

Chief Executive Officer
Name: Dr. Zsolt Török
Address: Biological Research Centre Hungarian Academy of Sciences Institute of Biochemistry H-6701 Szeged, Pf. 521
Tel.: 36-62-432038
Cell Phone: 36-30-5749295
Email: tzsolt@brc.hu
Date of Birth: July 31, 1965.
Nationality: Hungarian
Marital status: married, four children
EDUCATION
  • 1989 M.Sc. physics University of Szeged, Hungary
  • 1992 Ph.D. membrane biophysics Biological Research Center, Hungarian Academy of Sciences Institute of Biochemistry, Szeged, Hungary
PROFESSIONAL EXPERIENCE
  • 2007- CEO, LipidArt Ltd., Hungary
  • 2004- Head of Laboratory of Ultrasensitive Fluorescence Microscopy Institute of Biochemistry, Biological Research Centre, Hungarian Academy of Sciences, Szeged, Hungary
  • 1998- Senior scientist, Institute of Biochemistry, Biological Research Centre, Hungarian Academy of Sciences, Szeged, Hungary
  • 2002-2004 visiting scholar, Center for Biostabilization, University of California, Section of Molecular and Cellular Biology, University of California, Davis, USA
  • 1994-1998 Post doc Institute of Biochemistry, Biological Research Centre, Hungarian Academy of Sciences, Szeged, Hungary
  • 1992.1994 Post doc. long term EMBO fellowship, Centre for Biomembranes and Lipid Enzymology, Department of Biochemistry of Membranes, Utrecht University, Utrecht, The Netherlands
  • 1989-1992 Ph.D. student: Institute of Biochemistry, Biological Research Centre, Hungarian Academy of Sciences, Szeged, Hungary
RESEARCH INTERESTS understanding the role of biological membranes in sensing environmental stress (including pathophysiological conditions) using ultrasensitive fluorescence microscopy to study plasma membrane nanostructures role of stress proteins in membrane stabilization developing membrane lipid therapy for conditions in which stress resoponse is deregulated (cancer, neurodegenerative and metabolic diseases, aging) HONORS
  • 1992-1994 EMBO long term fellowship
  • 1997 Hans Selye Award
  • 1998 Academy Award for Young Scientist
  • 1998-2001 Bolyai János fellowship
  • 2005-2008 Bolyai János fellowship
Selected PUBLICATIONS (from a total of 51) Török, Z., Demel, R.A., Leenhouts, J.M., & de Kruijff, B. (1994) Presequence-mediated intermembrane contact formation and lipid flow. A model membrane study. Biochemistry 33, 5589-5594.
Török, Z.,Vígh, L. & Goloubinoff, P. (1996) Fluorescence detection of symmetric GroEL14(GroES7)2 heterooligomers involved in protein release during the chaperonin cycle. J. Biol. Chem. 271, 16180-16186.
Török, Z., Horváth, I., Goloubinoff, P., Kovács, E., Glatz, A., Balogh, G. & Vígh, L. (1997) Evidence for a lipochaperonin: Association of active protein-folding GroESL oligomers with lipids can stabilize membranes under heat shock conditions. Proc. Natl. Acad. Sci. USA 94, 2192-2197.
Vígh, L. Literáti, P.N., Horváth, I., Török, Z., Balogh, G., Glatz, A., Kovács, E., Boros, I., Ferdinándy, P., Farkas, B., Jaszlits, L., Jednákovics, A., Korányi, L. & Maresca, B. (1997) Bimoclomol: A nontoxic, hydroxylamine derivative with stress protein-inducing activity and cytoprotective effects. Nature Medicine, 3, 1150-1154.
Horváth, I., Glatz, A., Varvasovszki, V., Török, Z., Páli, T., Balogh, G., Kovács, E., Nádasdi, L., Benkő, S., Joó, F. & Vígh, L. (1998) Membrane physical state controls the signaling mechanism of the heat shock response in Synechocystis PCC 6803: Identification of hsp17 as a "fluidity gene". Proc. Natl. Acad. Sci. USA, 95, 3513-3518.
Török Z., Goloubinoff, P., Horváth, I., Tsvetkova, N., Glatz, A., Balogh, G., Varvasovszki, V., Los, D.A., Vierling, E., Crowe, J., Vígh, L. (2001) Synechocystis HSP17 is an amphitropic protein that stabilizes heat-stressed membranes and binds denatured proteins for subsequent chaperone-mediated refolding. Proc. Natl. Acad. Sci. USA, 98, 3098-3103.
Tsvetkova, N.M., Horváth, I., Török, Z., Wolkers, W.F., Balogi, Z., Shigapova, N., Crowe, L.M., Tablin, F., Vierling, E., Crowe, J.H. & Vígh, L. (2002) Small heat-shock proteins regulate membrane lipid polymorphism. Proc. Natl. Acad. Sci. USA 99, 13504-13509
Török, Z, Tsvetkova, N.M., Balogh, G., Horváth, I., Nagy, E., Pénzes, Z., Hargitai, J., Bensaude, O., Csermely, P., Crowe, J.H., Maresca, B. & Vígh, L. (2003) Heat shock protein coinducers with no effect on protein denaturation specifically modulate the membrane lipid phase. Proc. Natl. Acad. Sci. USA 100, 3131-3136.
Nagy E, Balogi Z, Gombos I, Akerfelt M, Bjorkbom A, Balogh G, Torok Z, Maslyanko A, Fiszer-Kierzkowska A, Lisowska K, Slotte PJ, Sistonen L, Horvath I, Vigh L. (2007) Hyperfluidization-coupled membrane microdomain reorganization is linked to activation of the heat shock response in a murine melanoma cell line. Proc. Natl. Acad. Sci. USA 104, 7945-7950
Balogh G., Péter M., Liebisch G., Horváth I., Török Zs., Nagy E., Maslyanko A., Benkő S., Schmitz G., Harwood J.L., Vigh L. (2010) Lipidomics reveals membrane lipid remodelling and release of potential lipid mediators during early stress responses in a murine melanoma cell line. Biochim. Biophys. Acta – Mol.Cell Biol. Lipids 1801, 1036-1047.
Gombos, I., Crul, T., Piotto, S., Güngör, B., Török, Z., Balogh, G., Péter, M., Slotte, J.P., Campana, F., Pilbat, A-M., Hunya, Á., Tóth, N., Literáti-Nagy, Z., Vigh Jr, L., Glatz, A., Brameshuber, M., Schütz, G.J., Hevener, A., Febbraio, M.A., Horváth, I., Vígh, L. (2011) Membrane-lipid therapy in operation: the HSP co-inducer BGP-15 activates stress signal transduction pathways by remodeling plasma membrane rafts. PLoS ONE 6, e28818. doi:10.1371/journal.pone.0028818
Török, Z., Pilbat A-M., Gombos I., Hocsak, E., Sümegi, B., Horváth, I. & Vígh, L. (2012) Evidence on cholesterol-controlled lipid raft interaction of the small heat shock protein Hspb11. In: Cellular trafficking of cell stress proteins in health and disease Eds: Henderson, B. & Pockley, A.G. ISBN: 978-94-007-4739-5.
Török, Z., Crul, T., Maresca, B., Schütz, G.J., Viana, F., Dindia, L., Piotto, S., Brameshuber, M., Balogh, G., Péter, M., Porta, A., Trapani, A., Gombos, I., Glatz, A., Gungor, B., Peksel, B., Vigh, L. Jr., Csoboz, B., Horváth, I., Vijayan, M.M., Hooper, P.L., Harwood, J.L., Vigh, L. (2014) Plasma membranes as heat stress sensors: From lipid-controlled molecular switches to therapeutic applications. BBA 1838, 1594-1618